????

?? > ???????? ??????QQ??

????????????“????”

 

??????QQ??,??QQ—501762377—?????????,??????,????????,????,?????,????,???????????????!v

????????????“????”




???

??????4?28?? (??)???????????????????????“CRISPR-Cas??”??????????????????????????????,?????crRNA???Cas??????????DNA??RNA,?????????

??“CRISPR-Cas??”?“sgRNA”?????????????DNA???,“CRISPRII-A????”??????Cas9(SpyCas9)????????????????????DNA??????????,????????????????????????????

??,?????????????,????????“??”?????????,????????????????“CRISPR-Cas??”?????????,????SpyCas9?????????????????????;???SpyCas9???????????????????,???????????????????????,??????“??”?????????……??,??????????????????????“???”?

28?,????????????,????????????????????Anti-CRISPR????SpyCas9???????,???SpyCas9??????????????,????????SpyCas9????????????????;?????????????????«??»(«Nature»)?????

?????,???????????Listeriamonocytogenes?????Anti-CRISPR??AcrIIA4?,????????SpyCas9???????,????Anti-CRISPR????SpyCas9???“????”??????

“SpyCas9?????????????,RNA??????????,SpyCas9???,??????????,???????????”??????,????????,SpyCas9??“?”?,???“??”?????????????,???????????,??????????,?????????

??????????????Anti-CRISPR????SpyCas9???????,?????????????????AcrIIA2?AcrIIA4?SpyCas9???????,??????????SpyCas9??????????????

??????????AcrIIA4??SpyCas9?????,???????????SpyCas9??,??:?????????,????,?SpyCas9??????????????????,???????????????,?????????“????”???,?????????“??”?(?)



????

???????????????????:??????????????2017-05-01 06:20:27

??????????????????????????3?????????2017-05-01 06:14:27

????????????1????20??????????2017-05-01 06:08:27

iphone4s???????????????????????????2017-05-01 06:02:27

?????????????,??????????????:???????34.8?2017-05-01 05:56:27

??QQ????.??????QQ??????!????????????????2017-05-01 05:50:27

???????????????????????????????????2017-05-01 05:44:27

??????????????????51?????72??????2017-05-01 05:38:27

??????????????????????????????2??? ??14?6??2017-05-01 05:32:27

???????????????????????? ?????????2017-05-01 05:26:27

????:???????????